Protein Details: Cation channel sperm-associated auxiliary subunit delta

Protein ID

ICDB_Pro_1391

Protein Name

Cation channel sperm-associated auxiliary subunit delta

Gene Name

CATSPERD; TMEM146; QtsA-17095; QtsA-17108; QtsA-19758

Organism

Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Length

793 amino acids

AlphaFoldDB

AF-Q95JI2-F1-model_v4.pdb

Function

Auxiliary component of the CatSper complex; a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane.

Sequence

MLMLMLVAAVTMWLRPLVTAQPLCRARTVRTGKVFNVIQDVQGDRLYFRSTTTRLIKHPCKKNIALYLGKQVFFTTDNFETSLLPFTIPTSMQVGVPEVTSAHFTGSLLLLVVNHKVYTYDYESNSWNLSLGIKHPVTHVSGDNCCYTGSLFCVDVSNLVFAYFRGDQISQTYIYYSNTGGFSFWKYHYDRQAEIVGSLGGIFHLFSLSQVGMLVVDQGKGMFKYSDHPLNRSLGLSFDYNGTLDIVIAPGQKGILLLWFEKSLLFSRNAGQLVDTVRVKKGEQTLFTSIFEAQITIHNIAVNENELAVITREDNLYYGNLGIVPSSIIKFAHQHIWSEDAALMFRSSGILEILTPVRDTAFAAFDFQKCLLNIQAILMDPDLHVGRCNIEFLKGEFTYRMYTIDMHSQLELTALLIPQPGTSLIPLVMVSNPHSLGFQATFYESGYTSDGNTKYKLDIYLKQQQHWGRTDFNFTSSLKRATMSTLTVDIANKEISCVDIKPLSTLISVGCDLDKKIVIQNTVSACSKGVLDALALQDNYSFIIEKEFYDPGFQGRQSSKDLHVFYSYQQLGCPLLVYYDTPWKPVVELWKKDRFQEVVDAEYVLLEVNGQFSYSYSLTAKSAMCTSQPQNWTTMIKESGGPFFWNRENYVSCHDPNNDAPLRWPDVQYQILGGRTANQIVFSHNNGFYVFYISIVDPYYSYCQLETVFSIYVYGAFPVQLVSAGVVMVLLISSILGSVWLAYMIPRLLRTARGRRMTSFVAQLYGRCKTVCQFRASATARTGSKPMGRHRSS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1186/1471-2164-3-36

RefSeq

Feature